The Buffalo Bills have officially released their 2025-26 NFL schedule, featuring a lineup of thrilling matchups from early September to late December, promising plenty of drama in the race for the playoffs.
The season kicks off with a home showdown against the Baltimore Ravens (Sept. 7) in NBC’s primetime slot — a golden opportunity for the Bills to showcase their strength against a formidable AFC opponent. A week later, they’ll travel to face the New York Jets (Sept. 14) before returning home for a Thursday Night Football clash against the Miami Dolphins (Sept. 18) on Prime Video.
At the end of September, the Bills will host the New Orleans Saints (Sept. 28) before a highly anticipated divisional matchup against the New England Patriots (Oct. 5). In Week 6, they’ll hit the road to take on the Atlanta Falcons (Oct. 13) in Monday Night Football before heading into their Bye Week.
The midseason stretch begins with a road trip to the Carolina Panthers (Oct. 26) and a marquee battle with the Kansas City Chiefs (Nov. 2). November brings more challenges, including trips to the Miami Dolphins (Nov. 9) and Houston Texans (Nov. 20), with a home game against the Tampa Bay Buccaneers (Nov. 16) sandwiched in between.
Closing out November, the Bills face the Pittsburgh Steelers (Nov. 30), then head into a high-pressure December featuring games against the Cincinnati Bengals (Dec. 7), a rematch with the New England Patriots (Dec. 14), and a road trip to the Cleveland Browns (Dec. 21). The regular season finale will be a home clash with the Philadelphia Eagles (Dec. 28), followed by a yet-to-be-scheduled “Flex Game” against the New York Jets.
With a schedule packed with powerhouse opponents both in and out of the AFC, the Buffalo Bills will need consistency, home-field dominance, and clutch performances in key moments to maintain their standing and keep their Super Bowl ambitions alive.
