San Francisco 49ers official 2025 schedule, Week 1-18 opponents, primetime games and bye week

The San Francisco 49ers finished the 2024 season with a 6-11 record. Kyle Shanahan will be hoping for a bounce-back year in 2025, as the team looks to return to the playoffs. Here is the 49ers’ schedule for the 2025 NFL season.

San Francisco 49ers 2025 NFL schedule

Week 1: @ Seattle Seahawks

Date & Time: Sunday, September 7th | 4:25 pm EST
Location: Lumen Field, Seattle, WA
Network: TBC

Week 2: @ New Orleans Saints

Date & Time: Sunday, September 14th | Time TBC
Location: Caesars Superdome, New Orleans, LA
Network: TBC

Week 3: vs. Arizona Cardinals

Date & Time: Sunday, September 21st | Time TBC
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC

Week 4: vs. Jacksonville Jaguars

Date & Time: Sunday, September 28th | Time TBC
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC

Week 5: @ LA Rams

Date & Time: Thursday, October 2nd | 8:15 pm EST
Location: SoFi Stadium, Inglewood, CA
Network: Amazon Prime

Week 6: @ Tampa Bay Buccaneers

Date & Time: Sunday, October 12th | 1:00 pm EST
Location: Raymond James Stadium, Tampa, FL
Network: TBC

Week 7: vs. Atlanta Falcons

Date & Time: Sunday, October 19th | 8:20 pm EST
Location: Levi’s Stadium, Santa Clara, CA
Network: NBC

Week 8: @ Houston Texans

Date & Time: Sunday, October 26th | 1:00 pm EST
Location: NRG Stadium, Houston, TX
Network: TBC

Week 9: @ New York Giants

Date & Time: Sunday, November 2nd | 1:00 pm EST
Location: MetLife Stadium, East Rutherford, NJ
Network: TBC

Week 10: vs. LA Rams

Date & Time: Sunday, November 9th | 4:25 pm EST
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC

Week 11: @ Arizona Cardinals

Date & Time: Sunday, November 16th | 4:05 pm EST
Location: State Farm Stadium, Glendale, AZ
Network: TBC

Week 12: vs. Carolina Panthers

Date & Time: Monday, November 24th | 8:15 pm EST
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC

Week 13: @ Cleveland Browns

Date & Time: Sunday, November 30th | 1:00 pm EST
Location: Huntington Bank Field, Cleveland, OH
Network: CBS

Week 14: BYE WEEK

Week 15: vs. Tennessee Titans

Date & Time: Sunday, December 14th | Time TBC
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC

Week 16: @ Indianapolis Colts

Date & Time: Monday, December 22nd | 8:15 pm EST
Location: Lucas Oil Stadium, Indianapolis, IN
Network: ESPN

Week 17: vs. Chicago Bears

Date & Time: Sunday, December 28th | 8:20 pm EST
Location: Levi’s Stadium, Santa Clara, CA
Network: NBC

Week 18: vs. Seattle Seahawks

Date & Time: Saturday, January 3rd or Sunday, January 4th | Time TBC
Location: Levi’s Stadium, Santa Clara, CA
Network: TBC