But that's not a definitive no. The Last of Us is a flagship franchise for Sony, and HBO's live-action adaptation already has plans to release at least another two seasons. The Last of Us isn't going to fade away anytime soon, and whether it's a few years or a few decades down the line, a third Last of Us game seems inevitable. When/if The Last of Us Part 3 happens, there are a handful of characters who could make a return.
Characters That Are Most Likely to Come Back For The Last of Us Part 3
Ellie
The heart of the franchise, Ellie would need to appear in at least some capacity in a hypothetical Last of Us Part 3. The Last of Us Part 2 ends with Ellie returning to a now-empty home, with Dina and baby JJ having left in the wake of Ellie setting off to kill Abby. Ellie's journey ends on a tragic note, but there's a hint of redemption there, and it'd be great to see that journey to redemption in a third Last of Us game.
Heartbroken by Ellie's decision to leave her and her son JJ in search of revenge once again, Dina disappears at the end of The Last of Us Part 2. It's unconfirmed where she and JJ went, but it's possible she went to stay with friends or family back in Jackson. If The Last of Us Part 3 ended up following Ellie's journey of redemption, then it would make sense for Dina to make an appearance, either to have one final confrontation with Ellie or to forgive her.
JJ
If The Last of Us Part 3 follows its predecessor's formula and jumps forward a few years, it would make sense for JJ to appear in the story. It might be a nice full-circle moment to have JJ be 14 years old when he meets Ellie again, the same age she was when she met Joel. Ellie could then take on a similar mentor role, though Naughty Dog would have to make sure that the plotline doesn't feel too cliché.
Tommy
The last time fans saw Tommy in The Last of Us Part 2, he was begging Ellie to head to Santa Barbara to avenge his brother. It's unclear what happens to Tommy after that final meeting, but there's room for him to appear in a potential Last of Us Part 3, perhaps as Ellie's only connection to her past with Joel.
Abby
After being enslaved, starved, and forced to fight Ellie, Abby is let go. Along with an unconscious Lev, Abby takes a boat and heads to Catalina Island, where she believes there to be a base of Fireflies. Regardless of where or when The Last of Us Part 3 is set, or who it centers on, an appearance from Abby would make a lot of sense given that she's essentially the second game's co-protagonist, and that her story still has so much room to grow.
Lev
Joel
Though Joel may not be around anymore, his impact on The Last of Us' cast could still be felt in a third game. Joel could reappear in flashbacks, from the perspective of Ellie, Tommy, or even Abby.